2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W929472
    13(S)-HOTrE 87984-82-5
    13(S)-HOTrE is an ester product.
    13(S)-HOTrE
  • HY-W930939
    (2S,3R,E)-2-Aminopentadec-4-ene-1,3-diol 86555-28-4
    (2S,3R,E)-2-Aminopentadec-4-ene-1,3-diol is an ester product.
    (2S,3R,E)-2-Aminopentadec-4-ene-1,3-diol
  • HY-W970428
    15-Methylheptadecanoic acid 29709-08-8
    15-Methylheptadecanoic acid is an ester product.
    15-Methylheptadecanoic acid
  • HY-W972380
    Methyl 2,6,10,14-tetramethylpentadecanoate 1001-80-5
    Methyl 2,6,10,14-tetramethylpentadecanoate is an ester product.
    Methyl 2,6,10,14-tetramethylpentadecanoate
  • HY-W982688
    Palmitoleyl methane sulfonate 93135-85-4
    Palmitoleyl methane sulfonate is an ester product.
    Palmitoleyl methane sulfonate
  • HY-W986917
    Decyl methanesulfonate 41233-29-8
    Decyl methanesulfonate is an ester product.
    Decyl methanesulfonate
  • HY-W988083
    Decarestrictin B 127393-91-3
    Decarestrictin B is a decanolactone that can be isolated from penicillium strains. Decarestrictin B is an inhibitor of cholesterol biosynthesis.
    Decarestrictin B
  • HY-W992384
    (S,9E,11Z,14Z)-8-Hydroxyicosa-9,11,14-trienoic acid 889573-69-7
    (S,9E,11Z,14Z)-8-Hydroxyicosa-9,11,14-trienoic acid is an ester product.
    (S,9E,11Z,14Z)-8-Hydroxyicosa-9,11,14-trienoic acid
  • HY-W992515
    9,10,16-Trihydroxyhexadecanoic acid 6949-98-0
    9,10,16-Trihydroxyhexadecanoic acid is an ester product.
    9,10,16-Trihydroxyhexadecanoic acid
  • HY-W997026
    Glucokinase activator 7 66780-67-4
    Glucokinase activator 7 is a Glucokinase activator. Glucokinase activator 7 can be used for research of diabetes, hyperglycemia and other diseases (Compound in Page 176 of Ref.).
    Glucokinase activator 7
  • HY-Y0078S1
    Cinnamyl Alcohol-d9
    Cinnamyl Alcohol-d9 is deuterated labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is a phenolic compound that is biologically toxic. 3-Methoxyphenol is systemically absorbed, disrupts the function of the liver, kidneys, central nervous system, and redox processes, and increases levels of Hb, red blood cells, and white blood cells in the body.
    Cinnamyl Alcohol-d9
  • HY-Y0136S1
    3-Indoleacetonitrile-d4 927182-31-8
    3-Indoleacetonitrile-d4 is deuterium labeled 3-Indoleacetonitrile. 3-Indoleacetonitrile is an endogenous metabolite.
    3-Indoleacetonitrile-d4
  • HY-Y0740S2
    4-Methoxybenzaldehyde-d2 95307-67-8
    4-Methoxybenzaldehyde-d2 is the deuterium labeled 4-Methoxybenzaldehyde (HY-W041300). 4-Methoxybenzaldehyde (p-anisaldehyde) is a fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking .
    4-Methoxybenzaldehyde-d2
  • HY-100775AR
    Fezagepras (Standard) 1002101-19-0
    Fezagepras (Standard) is the analytical standard of Fezagepras. This product is intended for research and analytical applications. Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras decreases renal, liver and pancreatic fibrosis. Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
    Fezagepras (Standard)
  • HY-100973AR
    Adenosine 5′-diphosphoribose sodium (Standard) 68414-18-6
    Adenosine 5′-diphosphoribose (sodium) (Standard) is the analytical standard of Adenosine 5′-diphosphoribose (sodium). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.
    Adenosine 5′-diphosphoribose sodium (Standard)
  • HY-101064S2
    Fmoc-leucine-d3 538372-74-6 98.50%
    Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
    Fmoc-leucine-d3
  • HY-101064S3
    Fmoc-leucine-d10 1190594-22-9 98.90%
    Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
    Fmoc-leucine-d10
  • HY-101409AR
    O-Acetyl-L-serine hydrochloride (Standard) 66638-22-0
    O-Acetyl-L-serine (hydrochloride) (Standard) is the analytical standard of O-Acetyl-L-serine (hydrochloride). This product is intended for research and analytical applications. O-Acetyl-L-serine hydrochloride is an endogenous metabolite.
    O-Acetyl-L-serine hydrochloride (Standard)
  • HY-101499AR
    GKT136901 hydrochloride (Standard) 1254507-01-1
    GKT136901 (hydrochloride) (Standard) is the analytical standard of GKT136901 (hydrochloride). This product is intended for research and analytical applications. GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
    GKT136901 hydrochloride (Standard)
  • HY-101903AR
    BMS-309403 sodium (Standard) 2802523-05-1
    BMS-309403 (sodium) (Standard) is the analytical standard of BMS-309403 (sodium). This product is intended for research and analytical applications. BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.
    BMS-309403 sodium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity